EGFR and non-small cell lung carcinoma: In a phase I/II clinical trial (AURA Study Phase II Extension Component, NCT01802632) [3] involving 198 evaluable patients with EGFR-TKI–pretreated EGFR- and T790M-positive non-small-cell lung cancer (NSCLC), showed that OSI leads to a promising median progression-free survival (PFS)(12.3 months, 95% confidence interval [CI], 9.5 to 13.8), and median durable response (15.2 months, 95% CI, 11.3 to not calculable).