About 27.2 % of patients with type 1 diabetes in DIVE/DPV reached a target HbA1c < 7.0 and 1.5 % (SGLT-2i)/0.6 % (GLP-1 RAs) received guideline-preferred anti-diabetic drugs as defined by the ESC/EASD [3]. This evidence concerns the gene GLP1R and type 1 diabetes mellitus.