Lastly, patient #2122 is a carrier of a VUS in the BRIP1 gene; this PABC patient was diagnosed five months post-partum with Luminal B-HER-2 negative breast cancer at 32 years of age and had a positive family history of cancer, including a first- and a second- degree relative with prostate and breast cancer respectively. The gene discussed is BRIP1; the disease is breast carcinoma.