Moreover, a wide range of indirect health benefits were reported in the guidelines, such as: a decrease of systolic and diastolic blood pressure, body fat, body weight, LDL-C, triglycerides, total cholesterol, HbA1c levels and new onset type 2 diabetes mellitus (T2DM); and an increase of HDL-C and insulin sensitivity. Here, INS is linked to type 2 diabetes mellitus.