The characteristic finding on magnetic resonance imaging (MRI) is unilateral cortical hyperintensities on T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) sequences.[3] Recently, a new term “FLAMES” has been proposed to characterize the clinical and radiological syndrome in patients with unilateral cortical FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures.[4] Here, we report a rare case of unilateral CCE with positive anti-MOG antibodies, which may expand the clinical phenotypes of MOG-antibody-associated disease (MOGAD). This evidence concerns the gene MOG and encephalitis.