Based on a TCGA dataset that included 261 sarcoma samples, the current study identified a prognostic signature which contained 3 methylation sites (cg07814289, cg09494609, and cg14144025) and corresponded to 3 genes (DNM1, RP11-983P16.4, and LINC01097) by combining differential methylation analysis, survival analysis, ROC analysis, and Cox regression analysis. This evidence concerns the gene LINC01097 and sarcoma.