DNM1 binds to the mitochondrial outer membrane via Fis1 and Mdv1 and assembles into higher oligomers at the mitochondrial surface, promoting the formation of rings and spirals that divide the organelle in a GTP-dependent manner.[20] Studies show that DNM1 is a hub gene in various tumor tissues such as pediatric medulloblastoma[21] and glioblastoma Multiforme.[22]RP11-983P16.4 is a long non-coding RNA (lncRNA) which is located on chromosome 12. This evidence concerns the gene FIS1 and glioblastoma.