Clinical trials have shown that LGZGD combined with Western medicine treatment can better improve heart function indicators, such as B-type brain natriuretic peptide (BNP) and LVEF, and promote the quality of life in CHF patients with Yang deficiency.[29,30] However, the previous systematic reviews of clinical trials for LGZGD in the treatment of CHF did not focus on the syndromes of the subjects, which fails to reflect the characteristics and advantages of TCM treatment. The gene discussed is NPPB; the disease is yang deficiency.