He et al reported, for the first time, a double amplification of CDK4 and MDM2 with protein overexpression by NGS and IHC in a 68-year-old woman with a gastric IMT with local invasion of spleen and diaphragm.[28] Furthermore, Antonescu et al found a correlation between genotype and specific clinical-pathological characteristics of IMT.[29] The authors tested all cases in the study for ALK gene rearrangements ALK-negative tumors were further studied by fluorescence in situ hybridization (FISH) and RNA sequencing for abnormalities in ROS1, PDGFRB, NTRK1, and RET. Here, CDK4 is linked to inflammatory myofibroblastic tumor.