He et al reported, for the first time, a double amplification of CDK4 and MDM2 with protein overexpression by NGS and IHC in a 68-year-old woman with a gastric IMT with local invasion of spleen and diaphragm.[28] Furthermore, Antonescu et al found a correlation between genotype and specific clinical-pathological characteristics of IMT.[29] The authors tested all cases in the study for ALK gene rearrangements ALK-negative tumors were further studied by fluorescence in situ hybridization (FISH) and RNA sequencing for abnormalities in ROS1, PDGFRB, NTRK1, and RET. This evidence concerns the gene PDGFRB and inflammatory myofibroblastic tumor.