METTL14 and osteosarcoma: METTL14 down-regulation would promote the metastatic potential of tumor cells through modulating the primary microRNA 126 process in hepatocellular carcinoma,[42] while it was reported as an oncogenic signal in acute myeloid leukemia.[43] In osteosarcoma, the expression of METTL14 was downregulated in osteosarcoma multidrug-resistant cells as well as tumor-initiating cell,[44] suggesting that it may play a vital role in the emergence and maintaining of osteosarcoma cells.