YTHDC1, a m6A reader, is a member of the YT521-B homology (YTH) domain family, which identifies the m6A group to exercise different downstream effects,[50,51] and was demonstrated to be associated with the progression of prostate cancer.[52] YTHDC1 was proved to be a prognostic factor in ovarian cancer with TP53 mutation,[53] but its prognostic role in osteosarcoma is still unknown. Here, TP53 is linked to osteosarcoma.