To our knowledge, elevated expression of PDGFA has been observed in various tumor types, such as head and neck squamous cell carcinoma, renal clear cell carcinoma, liver cancer, and lung cancer.[28] Additionally, Klimczak-Bitner et al found that PDGFA exhibited statistically higher expression level in EC tissues than in the corresponding normal samples.[29] As both ESCC and esophageal adenocarcinoma are main histopathological subtypes of EC, the expression of PDGFA in ESCC is still unknown. This evidence concerns the gene PDGFA and esophageal squamous cell carcinoma.