This speculation was consistent with several experimental studies on other types of cancers, which demonstrated that PDGFA promoted the invasion of cancer cells in oral squamous cell carcinoma,[10] papillary thyroid cancer,[13] and pancreatic cancer.[11,30] Additionally, Kaplan–Meier analysis showed that high PDGFA expression was associated with unfavorable prognosis ESCC patients, especially in advanced T stage. Here, PDGFA is linked to esophageal squamous cell carcinoma.