According to clinicopathological information obtained from GSE53625 dataset, the current study suggested that upregulation of PDGFA was significantly associated with advanced T stage, which was in accordance with the findings in nephroblastoma by Ghanem et al.[21] Obviously, the results about the increased PDGFA in higher T stage implied that PDGFA perhaps possessed the ability to promote the invasion of ESCC cells. This evidence concerns the gene PDGFA and Wilms tumor.