PDGFA and osteosarcoma: PDGFA overexpression is associated with decreased survival in some malignancies, for example, neuroblastomas,[19] osteosarcoma,[20] oral squamous cell carcinoma,[9] and gastric carcinoma,[18] while a few investigations demonstrated the opposite result in patients with nephroblastoma[21] and showed no significant associations between PDGFA and survival in renal clear cell carcinoma.[22] Although PDGFA has been reported to be crucial in different types of cancer, the expression profiles of PDGFA and its prognostic role in ESCC patients remain elusive.