PDGFA overexpression is associated with decreased survival in some malignancies, for example, neuroblastomas,[19] osteosarcoma,[20] oral squamous cell carcinoma,[9] and gastric carcinoma,[18] while a few investigations demonstrated the opposite result in patients with nephroblastoma[21] and showed no significant associations between PDGFA and survival in renal clear cell carcinoma.[22] Although PDGFA has been reported to be crucial in different types of cancer, the expression profiles of PDGFA and its prognostic role in ESCC patients remain elusive. The gene discussed is PDGFA; the disease is esophageal squamous cell carcinoma.