VDR and intervertebral disk degenerative disorder: A recent review analyzed seven meta-analyses and concluded that there is no evidence of an association between FokI polymorphism and IDD in the general population.[12] However, such a conclusion is not supported other meta-analyses: a meta-analysis performed by Chen et al[8] demonstrated that the VDR FokI polymorphism may be associated with disc degeneration susceptibility among Caucasians; Pabalan et al[11] performed a meta-analysis and found that VDR ApaI polymorphism may be a protective role in disc degeneration but the VDR FokI polymorphism may be ethnic and gender specific.