Based on the available evidence at present this meta-analysis found VDR FokI polymorphisms was associated with disc degeneration risk among Caucasians but not Asians, VDR TaqI polymorphisms was associated with disc degeneration risk among Asians but not Caucasians, there was also an obvious association between VDR ApaI polymorphism and disc degeneration risk among Asians and Caucasians. The gene discussed is VDR; the disease is intervertebral disk degenerative disorder.