According to the inclusion and exclusion standard, a total of 23 studies[15–37] published from 2003 to 2019 were included in this meta-analysis: 16 studies with 2109 cases and 2454 controls for VDR FokI mutation and risk of disc degeneration; 13 studies with 1918 cases and 2019 controls for VDR TaqI mutation and risk of disc degeneration; 7 studies with 1152 cases and 1251 controls for ApaI mutation and risk of disc degeneration. The gene discussed is VDR; the disease is intervertebral disk degenerative disorder.