VDR and intervertebral disk degenerative disorder: Zhao et al.[7] performed a meta-analysis and found that FokI polymorphism is not generally associated with disc degeneration, but there is increased risk for disc degeneration in Hispanics and Asians carrying FokI allele T. Several meta-analyses were performed subsequently but the conclusions still remains controversial.[8–12] After that a series of novel studies have been performed, so an updated meta-analysis based on 23 studies was performed to clarify the effect of VDR gene polymorphisms (TaqI, FokI and ApaI) on the risk of disc degeneration.