In one report,51 induced hypothyroidism had no effect on cone opsin expression in adult mice after 2 weeks, whereas Glaschke et al.24reported changes in the opsin expression pattern first at 5 to 7 weeks after serum thyroid hormones decreased to hypothyroid levels, concluding that the process may be influenced by the duration of hypothyroidism. The gene discussed is TG; the disease is hypothyroidism.