TKT and Increased circulating aldosterone concentration: Previous studies in TK-deficient mice indicate that TK has antihypertensive effect in the pathological situations of mineralocorticoid excess and salt retention but not in non-hypertensive animals (Meneton et al., 2001; Potier et al., 2013), while another study on gene therapy shows a prolonged reduction in systemic BP by adenovirus-mediated human TK gene delivery into SHR (Wang et al., 2004); all of these findings are in accordance with our results.