SERPINA1 and hyperinsulinemic hypoglycemia, familial, 4: The screen was performed in cells expressing the highly polymerogenic King’s variant, that although not the most common α1AT mutant, recapitulates the phenotype observed in cells expressing the most common Z-α1AT variant and results in polymers that share the same structure, supporting the use of King’s mutant as a representative and comparable polymerogenic model of α1AT deficiency disease (Miranda et al., 2010; Ordóñez et al., 2013).