In summary, our results indicated that PD maintains the epithelial barrier by inhibiting intestinal inflammation, and the mechanism of the anti‐inflammatory effects is likely through the inhibition of MAPKs, the NF‐κB inflammation signaling pathway, and the AKT/Nrf2/HO‐1/NQO1 mediated antioxidant signaling pathway. This evidence concerns the gene AKT1 and Parkinson disease.