We found that TGFBR3 overexpression significantly decreased the expression level of TGFBR1, TGFBR2 and p-SMAD3, which could be obviously reversed by miR-107 overexpression in the two PC cells (Fig 5A), in addition, the original uncropped and unadjusted images underlying all blot were presented in S1 File. Here, TGFBR3 is linked to pachyonychia congenita.