We found that TGFBR3 overexpression significantly decreased the expression level of TGFBR1, TGFBR2 and p-SMAD3, which could be obviously reversed by miR-107 overexpression in the two PC cells (Fig 5A), in addition, the original uncropped and unadjusted images underlying all blot were presented in S1 File. The gene discussed is SMAD3; the disease is pachyonychia congenita.