The emPAI value (0.28) for POTEE, the primate-specific POTE (prostate, ovary, testis and embryo expressed) ankyrin domain family member E that promotes CRC growth [38], indicates this protein is a general target of S-nitrosylation in CDX tumors from Hltf-deleted and control TME. Here, HLTF is linked to colorectal carcinoma.