Pre-treatment of K18-ACE2 mice with diABZI-4 resulted in a decrease in the expression of numerous SARS-CoV-2 genes including N-protein (Fig. 3G), Nsp14 (Fig. 3H) and ORF1 (Fig. 3I) in lung tissue collected 48 hours post-infection. The gene discussed is KRT18; the disease is infection.