MYC and glioma: For example, a conditional transgenic mouse modelfor MYC-induced tumorigenesis demonstrated that brief inactivationof cMYC was sufficient to elicit sustained regressionof transplanted osteogenic sarcoma cells,7 and knockdown of cMYC in glioma cancer stem cellsreduced proliferation with concomitant cell cycle arrest and increasedapoptosis, whereas nonstem glioma cells displayed limited dependenceon MYC expression for survival and proliferation.8