Deregulation of MYC-familyoncogenes (i.e., cMYC, MYCN, and MYCL)is associated with a poor prognosis and unfavorable survival of cancerpatients.1 Amplification of MYC-family oncogenes has been observed in 28% cancers in The CancerGenome Atlas (TCGA).2 Sustained MYC-familyprotein levels can initiate tumor formation, accelerate tumor progression,and help in tumor maintenance. The gene discussed is MYCN; the disease is neoplasm.