As in Offer et al. [43], our cohort included variants in MLH3, MSH3, and MRE11A. We identified 15 novel variants in known PID genes: AICDA, ATM, DCLRE1C, CHD7, PRKDC, RAG1, and RNF168. A GWAS of CVID found that many of the identified variants were unique to individual patients [7] and recent whole exome sequencing uncovered mostly novel rather than published variants [44]. This evidence concerns the gene MLH3 and common variable immunodeficiency.