Additionally, TFPI2 (AUC = 0.855, 95% CI 0.778–0.933) was superior to CA125 (AUC = 0.520, 95% CI 0.392–0.650) in discrimination of CCC patients, even at stage I (AUC of TFPI2: 0.811; AUC of CA125: 0.579), from endometriosis patients (Fig. 2b–d and Supplementary Table 4). Here, TFPI2 is linked to endometriosis.