Given systemic CX3CL1 elevation in human CKD and in controlled murine models (Chang et al. 2014; Shah et al. 2015; Luo et al. 2019; Roy-Chowdhury et al. 2020, p.; Li et al. 2020), new discoveries regarding regulatory mechanisms and remote effects of this pathway are discussed for their relevance in kidney disease. This evidence concerns the gene CX3CL1 and kidney disorder.