CX3CR1 and Hypertension: Also in kidney fibrosis induced by hypertension, while an earlier report describes aggravation by CX3CR1 in DOCA salt–treated mice (Shimizu et al. 2011), a more recent study found less renal hypertensive damage in unilaterally nephrectomized angiotensin II-infused mice on a high salt diet in the presence of CX3CR1 than in its absence (Ahadzadeh et al. 2018).