Furthermore, lymphocyte sub-sets in GC have also been considered, hinting a significant correlation between TILs, expressed as CD4+/CD8+ T cells tissue ratio, and survival [12, 16, 17], while other studies focused on high microsatellite instability, MSI-H and PD-L1 expression, as a potential indicator of resistance to NAD-CT [12, 18, 19]. The gene discussed is CD8A; the disease is gastric cancer.