CD4 and neoplasm: At the same time, we evaluated the peritumoral microenvironment, where the immune host cells (mainly lymphocytes) strictly interacted with neoplasm, demonstrating, in agreement with other authors [12, 16, 17], the significant association with low CD4+/CD8+ T cell ratio with PFS, OS (both p < 0.001), and the pathological response to NAD-CT (as TRG) in our cohort (p = 0.003).