Amidst the duct subpopulation markers, Spp1 and Anxa3 caught our eye due to their known roles in pancreatic cancer progression (Kolb et al., 2005; Adams et al., 2019; Wan et al., 2020); however, their functions in normal pancreatic duct epithelium have not been fully explored. This evidence concerns the gene SPP1 and familial pancreatic carcinoma.