So far, mutations in WNT10A and WNT10B havebeen shown to cause syndromic tooth agenesis (in combination withmalformation of other epithelial-derived organs such as hair and glands) anda nonsyndromic type of tooth agenesis in humans (Adaimy et al. 2007; Yu et al. 2016).In this study, we introduce the WNT ligand (WNT1) to be important foralveolar bone and cementum formation. This evidence concerns the gene WNT10A and tooth agenesis.