11 Nyberg Nyberg M M Mortensen Mortensen SP SP Hellsten Hellsten Y Y Physical activity opposes the age-related increase in skeletal muscle and plasma endothelin-1 levels and normalizes plasma endothelin-1 levels in individuals with essential hypertension Physical activity opposes the age-related increase in skeletal muscle and plasma endothelin-1 levels and normalizes plasma endothelin-1 levels in individuals with essential hypertension Acta Physiol (Oxf) Acta Physiol (Oxf) 2013 2013 207 207 3 3 524 524 535 535 23227981 23227981 11. This evidence concerns the gene EDN1 and hypertensive disorder.