In summary, our results indicated that MARVELD1 exerted a tumor-promoting impact on the malignant phenotype of glioma cells via activating JAK/STAT signaling pathway in vitro. It could be a potential effective target for glioma therapy, but these findings are limited to glioma cell lines in vitro, and the function of MARVELD1 in glioma in vivo needs further research. This evidence concerns the gene MARVELD1 and glioma.