MARVELD1 and central nervous system cancer: In summary, our results indicated that MARVELD1 exerted a tumor-promoting impact on the malignant phenotype of glioma cells via activating JAK/STAT signaling pathway in vitro. It could be a potential effective target for glioma therapy, but these findings are limited to glioma cell lines in vitro, and the function of MARVELD1 in glioma in vivo needs further research.