RHO and cancer: RhoA and its GEFs Vav and Trio are also overexpressed in particular cancers although, as with Cdc42, its inherent ability to function in both migration and polarity means it may act as either a tumorigenic factor or tumor suppressor.69,70 Rho-ROCK and Cdc42-MRCK-signaling have been demonstrated to converge during actomyosin-dependent cell motility.71 Rho-ROCK is important for tumor cell migration through a three-dimensional matrix with a rounded morphology, whereas Cdc42-MRCK co-operates with Rho-ROCK to generate and maintain elongated morphology and invasion.