Of note, the released HMGB1 during the infection of various viruses, such as respiratory syncytial virus (RSV) [16,55], hepatitis C virus (HCV) [56], Herpes simplex virus type 2 (HSV-2) [13,57], and HSV-1 [58], has been convinced to exacerbate severity of the inflammatory disease [12]. Here, HMGB1 is linked to infection.