Pajtler et al. presented an epigenetic classification of ependymomas which divides supra-, infratentorial and spinal ependymomas into three different, partly age-related, and prognostically relevant groups each: spinal subependymoma (SP-SE), spinal myxopapillary ependymoma (SP-MPE), spinal ependymoma (SP-EPN), posterior fossa subependymoma (PF-SE), posterior fossa ependymoma-A (PF-EPN-A), posterior fossa ependymoma-B (PF-EPN-B), supratentorial subependymoma (ST-SE), supratentorial ependymoma YAP1-fused (ST-EPN-YAP), and supratentorial ependymoma RELA-fused (ST-EPN-RELA) [11]. This evidence concerns the gene RELA and posterior fossa ependymoma.