At date of PCa diagnosis, men older than 80 years, compared with men under 70, more often had advanced local tumor stage (T3–T4) (44% vs. 14%), higher PSA levels (median, 29 vs. 8 ng/mL), more often had Gleason score 8 or 9–10 (33% vs. 13%) and more often had distant metastases (14% vs. 6%). This evidence concerns the gene KLK3 and posterior cortical atrophy.