Other potential explanations for the increase in free serum DHA among APOE ε4 may be that this reflects greater activation of phospholipase A2, which liberates esterified DHA from phospholipid,52 suggesting that the increase in DHA is a biomarker of another processes such as enhanced vascular inflammation as opposed to being directly linked to Alzheimer’s disease pathology. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.