M2 downregulation in TNBC (Figure 3) was evident for M2 genes TFF1 and SCUBE2, and their transcript levels also predict BrCa survival (Figure S1 and Table 2), as previously reported for TFF1, with established roles in the inhibition of proliferation, migration, and invasion of BrCa cells in vivo (Yi et al., 2020). This evidence concerns the gene SCUBE2 and invasive breast carcinoma.