Compared with the common homozygous genotype, the effect of the GC or GC + CC variant genotypes for COL1A1 rs2269336 and the TC or TC + CC genotypes for BRAF rs76603725 was more evident in males, liver cirrhosis, tumor number ≥3, tumor maximum diameter ≥5 cm, and tumor in two lobes. This evidence concerns the gene COL1A1 and cirrhosis of liver.