EGFR and biliary tract neoplasm: However, in our studies with solid tumors, no event of grade 3 or 4 neurotoxicity was reported with CAR-T administration and one episode of grade 3 cytokine release syndrome was reported with acute respiratory distress that required tocilizumab injection with EGFR-specific CAR-T cells in biliary tract cancers [16]. The use of high-intensity conditioning chemotherapy in hematological malignancies has shown to increase T cell persistence and efficacy and has shown beneficial response in decreasing the incidence and severity of cytokine release syndrome [38].