Serum PGC-1α showed a potential predictive value of AF with an AUC of 0.633 (95% CI: 0.555-0.711; P = 0.001), and the optimum cutoff value was 463.5 with a sensitivity of 65.6% and a specificity of 57.3%. Here, PPARGC1A is linked to atrial fibrillation.