G6PD and myocardial infarction: The injury of cardiomyocytes during experimental myocardial infarction seems to be directly dependent on the activity of G6PD; in a murine model of myocardial ischemia, the administration of benfotiamine, a PPP activator capable of increasing the activity of G6PD and transketolase, improves the vascularization of the peri-infarct area and limits the extension of myocardial damage [167].