In a large series of patients from Sardinia undergoing upper endoscopy with a known G6PD status and a complete clinical history, including established CVD risk factors and H. pylori infection, after adjusting for potential confounders, an overall increased CVD risk in subjects with G6PD deficiency (OR 3.24; 95% CI 2.44–4.30) was confirmed [150]. The gene discussed is G6PD; the disease is G6PD deficiency.