Table 3 showed information about the ten genes with a higher R2 value. A total of 114 prognostic genes were screened by Cox regression model to eliminate the nonprotein-coding genes. Finally, 97 prognostic genes were obtained. After searching on EBI, we excluded DTNBP1, which was linked to lung squamous cell carcinoma in previous studies [38]. In addition, we have identified a smoking-related gene, ASB18, which may further influence the development of lung cancer [39]. Here, ASB18 is linked to squamous cell lung carcinoma.