But the response rate of the drug is only 15–20% [11], and the possible mechanism of evasion is mediated by the upregulation of interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF) expressions, two major proteins that regulate angiogenesis, drug resistance, and tumor cell growth by an autocrine mechanism [12–14]. This evidence concerns the gene VEGFA and neoplasm.