As shown in Figure 6, the mRNA expressions of PPAR-α, AdipoR2, and CPT1 in the liver of NAFLD rats were significantly downregulated (P < 0.05), while the expressions of SREBP-1c and CYP2E1 were markedly upregulated (P < 0.01), as compared with the normal control group. Here, CYP2E1 is linked to metabolic dysfunction-associated steatotic liver disease.