In some studies, it is shown that the extract of the warm-natured drugs such as Allicin [72] and astragaloside IV [73], through regulating sarcoplasmic reticulum Ca2+ pump, improved the distribution and expression of PECAM-1, enhanced the migration and angiogenesis ability of cardiac microvascular endothelial cells, promoted angiogenesis, protected myocardial ischemia, inhibited cardiac hypertrophy and fibrosis, and reduced myocardial cell apoptosis. Here, PECAM1 is linked to cardiac hypertrophy.