PECAM1 and myocardial ischemia: In some studies, it is shown that the extract of the warm-natured drugs such as Allicin [72] and astragaloside IV [73], through regulating sarcoplasmic reticulum Ca2+ pump, improved the distribution and expression of PECAM-1, enhanced the migration and angiogenesis ability of cardiac microvascular endothelial cells, promoted angiogenesis, protected myocardial ischemia, inhibited cardiac hypertrophy and fibrosis, and reduced myocardial cell apoptosis.