Consistent with this, prevention of EGFR inhibitor-induced acne by skin irradiation is attributable to FGFR2 downregulation [102]; FGF7-activated FGFR2b causes TGFα-induced EGFR signaling [103], completing a homeostatic FGFR2-EGFR control loop. Here, EGFR is linked to acne.