TP53 and colorectal carcinoma: Two p63α isoforms are transcribed from different promoters: a proapoptotic transcriptionally activating (TA) isoform that includes an N-terminal transactivation domain, called TAp63α, which is the main p63 isoform expressed in normal colon and overexpressed in CRC [210]—in which context it exerts a tumor-suppressive effect [211]—and a dominant-negative p53-inhibitory N-terminal-truncated (ΔN) isoform lacking the transactivation domain, called ΔNp63α, which is the main isoform in keratinocytes [212].