Common hardwired cancer-associated FGFR genotypes include FGFR1 amplification (e.g., in lung cancers, uveal melanomas, low-grade gliomas, or drug-refractory breast cancers [39, 123, 124]), FGFR3 mutations (e.g., in superficial papillary urothelial cancers [125, 126]), and FGFR2 gene fusions (especially in fluke-negative intrahepatic cholangiocarcinomas [127]). The gene discussed is FGFR2; the disease is breast carcinoma.