TNF and American trypanosomiasis: KEGG analysis revealed that key targets were mainly enriched in 15 signal pathways, as shown in Figure 8, including pathways in cancer, PI3K-Akt signaling pathway, prolactin signaling pathway, progesterone-mediated oocyte maturation, prostate cancer, proteoglycans in cancer, estrogen signaling pathway, Chagas disease (American trypanosomiasis), osteoclast differentiation, Ras signaling pathway, TNF signaling pathway, colorectal cancer, hepatitis B, and epithelial cell signaling in Helicobacter pylori infection.