USP22 and cancer: Noteworthy, USP22 also modulates the stability and function of multiple non-histone targets associated with cancer progression and poor prognostic outcome including c-Myc, Cyclin D1, Cyclin B1, EGFR, SOS, SIRT1, COX2, XPC, KDM1A, ERa, SHH [10–19], as well as nodal immunologic factors [20–22].