Interestingly, the regulation of UPR by USP22 might not be limited to the HER2+-BC subtype, as an enrichment of UPR-specific gene signatures was also observed in mRNA-seq datasets of normal immortalized mammary epithelial cells (MCF10A) and prostate carcinoma cells (LNCaP) upon USP22 knockdown (Fig. S3A-B). Here, ERBB2 is linked to prostate carcinoma.