In fact, BTZ-induced tubulin polymerization has already been demonstrated in multiple myeloma cells (HCN2 and RPMI 8226), renal carcinoma cells (786-0), neuroblastoma cells (KCNR and SH-SY5Y)32 as well as in E15 rat DRG neurons7,28, in adult rat DRG neurons and in the sciatic nerve of BTZ-treated rats7. This evidence concerns the gene CASC3 and renal carcinoma.