CD4 and myeloid sarcoma: CD4+CD25+CD45RA−Foxp3hi cells (Population II), the most suppressive of the three Populations43, was significantly increased in CD4+CD25+CD127loTreg in all MS patients (n = 36, p = 0.0017) (Fig. 2C) and treatment naïve MS patients (n=12, p < 0.018) (Fig. 2F) compared to HD.