The populations of TILs (CD4+ and CD8+) and cytotoxic TILs (CD8+granzyme B+) in primary and distant tumor tissues and spleen of SPNpro-injected mice were higher than that of SPN-1- or SPN-2-injected mice after NIR photoirradiation (Fig. 5a, Supplementary Fig. 17). The gene discussed is CD4; the disease is neoplasm.