The green fluorescence signals of FITC-labeled anti-caspase-3 antibodies were detected in the primary tumor tissues of SPNpro-, SPN-1-, and SPN-2-injected mice after photoirradiation, which were 33.1-, 21.8-, and 24.2-fold higher than the saline-injected mice, respectively (Fig. 4i, Supplementary Fig. 14a). This evidence concerns the gene SSPN and neoplasm.