Screening of obesity-associated proinflammatory cytokines and chemokines in subcutaneous white adipocytes demonstrated that BAFF, but not APRIL, upregulated the mRNA expression of multiple proinflammatory mediators, including Tnf, Cxcl1, Ccl2, and Ccl3 (Supplemental Fig. 15b–e). Here, CXCL1 is linked to obesity due to melanocortin 4 receptor deficiency.