In this regard, even a minimal increase in BAFF (~20% increase in RP105−/− mice) are protective of DIO and would likely not cause the deleterious effects observed with log-increases of BAFF76,77 (e.g., autoimmunity, B-cell-driven pathology) invoking therapeutic potential in humans. The gene discussed is TNFSF13B; the disease is Autoimmunity.