Screening of obesity-associated proinflammatory cytokines and chemokines in subcutaneous white adipocytes demonstrated that BAFF, but not APRIL, upregulated the mRNA expression of multiple proinflammatory mediators, including Tnf, Cxcl1, Ccl2, and Ccl3 (Supplemental Fig. 15b–e). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.