MAPK3 and Cornelia de Lange syndrome: Genes that were downregulated in Rad21Tev/Tev neurons 24 h after ERt2-TEV-induced cohesin depletion showed, as a set, significant downregulation also in CdLS patient neurons (NES = −2.15, FDR = 5.6 × 10−4, Fig. 3a).