Accordingly, a significant number of genes were deregulated both in CdLS patient neurons and after acute cohesin depletion of mouse neurons (51 in CdLS and ERt2-TEV, 57 in CdLS and NLS-TEV, 81 shared overall, Odds ratio = 2.48, P = 4.87e-11, of which 55 were downregulated, Odds ratio = 3.14, P = 4.06e-11). This evidence concerns the gene MAPK3 and Cornelia de Lange syndrome.