Again, protein levels of PBX3, Ki67, PCNA, BCL-2, and p-ERK/ERK were reduced in the AML cells infected with LV-miR-224-5p, all of which could be reversed by following PBX3 overexpression, leading to increased protein expression levels (Fig. 7f, g). The gene discussed is MKI67; the disease is acute myeloid leukemia.